怎样治疗支原体

如何治疗支原体配图，仅供参考

Treatment Options for Mycoplasma Genitalium Infection are Limited by Antimicrobial Resistance
Treatment of MG urogenital infection is important from the view point of transmission and complications. Due to the lack of cell wall,limited antibiotic options are available. Tetracyclines,macrolides,and fluoroquinolones have activity against Mycoplasmas. Therapy for MG is indicated if detected in any genitourinary sample in symptomatic patients or as part of an epidemiological survey. Macrolides remain the mainstay of therapy in susceptible infections and have been covered under the syndromic approach for genito-urinary discharge. It achieves a good cure rate of 85%–95% in susceptible infections as single dose therapy . However,increasing macrolide resistance has been reported with the widespread use of azithromycin 1 g single dose without test of cure.
Azithromycin is recommended as the first-line agent for the treatment of uncomplicated MG infections (including in pregnancy). Individuals who have not received previous empirical treatment for urethritis or cervicitis with single-dose azithromycin should receive an extended oral macrolide regimen with azithromycin 500 mg on day 1,then 250 mg on days 2–5. In treatment failure or with confirmed macrolide-resistant infection,moxifloxacin is recommended. Treatment failure with moxifloxacin is uncommon. Test of cure is recommended only in those with persistent symptoms after treatment.
An extended oral macrolide regimen with azithromycin or Josamycin 500 mg three times daily for 10 days drastically improves the cure rate. Macrolide resistance rates vary significantly geographically,but where azithromycin 1 g single dose is used for the treatment of NGU,it is usually found in 30%–45% of samples.
Josamycin is widely used in Russia with 500 mg three times a day for 10 days but will not eradicate macrolide-resistant strains. Moxifloxacin can be used as second line therapy or for complicated cases for 7–14 days. Moxifloxacin is the most commonly used second line antimicrobial. It is bactericidal and has a cure rate approaching 100% in infections with susceptible strains. However,resistance has developed with treatment failures ranged from 5% to 47.1% primarily in patients from the Asia-Pacific region.
Doxycycline in a dose of 100 mg two times daily for 14 days has a low cure rate of 30%–40% but does not increase resistance.","department":"