新人999如何治疗湿疣疱疹配图，仅供参考
TreatmentFor genital herpes and visceral HSV infections,the DNA nucleoside analogues,including acyclovir,famciclovir and valacyclovir are the mainstays of therapy. While acyclovir and its related compounds have a limited side effect profile,intravenous acyclovir can lead to crystallization in the renal outflow tract though this can be largely avoided with adequate hydration. Intravenous therapy is warranted for visceral disease,neonatal herpes and encephalitis .
Drug resistant HSV is largely limited to the immunocompromised host and can be treated with foscarnet or cidofovir. Foscarnet commonly causes renal insufficieny,elctrolyte wasting and nausea . Cidofovir is dosed weekly,is also nephrotoxic,commonly causes rash and chills,and needs to be dosed with probenecid. Patients also need to be monitored for leucopenia .
DNA nucleoside analogues have proven efficacy in limiting the duration of first-episode genital herpes infection,and in limiting the duration and severity of recurrences. It is now recognized that short course therapy is often a conveneient and inexpensive option for recurrences in immuncompetent patients ). The DNA nucleoside analogues can be taken prophylactically on a daily basis to limit recurrence frequency,asymptomatic shedding,and to decrease HSV-2 transmission between serodiscordant monogamous couples ) .
# Table 1
CDC recommended treatment regimens for genital herpes .
First episode
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Acyclovir 400 mg orally three times a day for 7 – 10 days
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Acyclovir 200 mg orally five times a day for 7 – 10 days
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Famciclovir 250 mg orally three times a day for 7 – 10 days
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Valacyclovir 1 g orally twice a day for 7 – 10 days
Suppressive therapy for recurrent genital herpes
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Acyclovir 400 mg orally twice a day
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Famciclovir 250 mg orally twice a day
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Valacyclovir 1 g orally daily
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Valacyclovir 500 mg orally daily
Episodic therapy for recurrent genital herpes
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Acyclovir 400 mg orally three times a day for 5 days
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Acyclovir 800 mg orally two times a day for 5 days
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Acyclovir 800 mg orally three times a day for 2 days
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Famciclovir 125 mg orally two times a day for 5 days
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Famciclovir 1 g orally two times a day for 1 day
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Valacyclovir 500 mg orally twice a day for 3 days
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Valacyclovir 1000 mg orally daily for 5 days
Suppressive therapy for recurrent genital herpes in HIV infected patients
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Acyclovir 400–800 mg orally twice or three times a day
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Famciclovir 500 mg orally twice a day
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Valacyclovir 500 mg orally twice daily
Episodic therapy for recurrent genital herpes in HIV infected patients
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Acyclovir 400 mg orally three times a day for 5–10 days
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Famciclovir 500 mg orally twice a day for 5–10 days
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Valacyclovir 1 g orally twice daily for 5–10 days
[Open in a separate window](https://ncbi.nlm.nih.gov/pmc/articles/PMC2804398/table/T1/?report=objectonly)
Extension of therapy beyond ten days is appropriate if lesions healing has yet to occur.","department":"
