尖锐湿疣怎样治疗最好

尖锐湿疣如何治疗最好配图，仅供参考

Patient-administered therapies
Patient-administered therapies include podofilox (0.5%) solution or gel,imiquimod 3.75 or 5% cream,and sinecatechins (polypheron E) 15% ointment.,Podofilox (0.5%) solution or gel is derived from podophyllotoxin,a plant resin that works by disrupting microtubules during cell cycle replication,arresting mitosis,and causing tissue necrosis,and has been shown efficacious in the treatment of penile warts.,Podofilox (0.5%) solution or gel is applied topically twice a day for 3 consecutive days per week and can be applied at home. The weekly cycle can be repeated up to four times. Clearance rates range from 45 to 77%. Adverse events include local discomfort,pruritus,irritation,burning,pain,xerosis,erythema,erosion,ulceration,and postinflammatory pigmentary changes at the site of application.,To minimize local adverse events,podophyllotoxin should be washed off 1–4 hours after application. Sexual intercourse should be avoided when podophyllotoxin is still on the skin.
Imiquimod is available as 3.75 and 5% cream. Imiquimod enhances the host’s innate and cellular immune response and combats HPV infection by binding to the dermal dendritic cells and macrophages through toll-like receptor-7. This results in the production and release of proinflammatory cytokines,such as interferon alpha (IFN-α),tumor necrosis factor alpha (TNF-α),and interleukin (IL)-1,IL-6,IL-8,and IL-12.,The secreted cytokines stimulate local immune effects that are cytotoxic against HPV. Imiquimod also acts on cell-mediated immunity by activating Langerhans cells,thereby increasing the presentation of antigens for the T cells. Studies have shown that topical application of 5% imiquimod cream is beneficial in the treatment of penile warts. The 5% imiquimod is applied three times per week till total clearance of the lesion or for a maximum of 16 weeks,while the 3.75% imiquimod is applied nightly for up to 8 weeks.,Clearance rates are similar to those of podofilox. Adverse events with topical imiquimod include local irritation,pruritus,burning,erythema,vesicles,erosions,ulceration,and hypopigmentation at the application site and,less frequently,flu-like symptoms.,To minimize local adverse events,the treatment area should be washed with soap and water 6–10 hours after application.
Sinecatechins ointment is a water extract of leaves of green tea (Camellia sinensis) and available as 10 and 15% formulations. It is believed that the medication works by decreasing viral replication through upregulation of apoptosis-associated genes and modulation of genes involved in the proinflammatory response to HPV infection.,Sinecatechins ointment is a safe and effective treatment of penile warts in immunocompetent males aged 18 years and older.,It is recommended that sinecatechins ointment be applied three times a day for up to 16 weeks.,It is not necessary to wash the ointment off prior to the next application. Two randomized,double-blind,phase III trials (n=1005) showed rates of complete clearance and recurrence after 12 weeks of genital warts were significantly superior to the control group (p