怎样治疗肝纤维化

如何治疗肝纤维化配图，仅供参考

Anti-inflammatory drugs reduce liver inflammation
Anti-inflammatory drugs,including corticosteroid,prednisone,and prednisolone,suppress cytokine transcription,thus inhibiting hepatic collagen deposition . These drugs can only effectively and safely treat liver fibrosis in combination with azathioprine .
Genistein (Figure ) is a type of isoflavone first isolated from Hydrocotyle sibthorpioides (Tianhusui) and considered a potent chemopreventive agent with estrogenic activities against breast cancer . Treatment with genistein decreased levels of inflammation mediators,including IL-6,TNF-α,and myeloperoxidase,through downregulation of NF-κB in alcohol- and CCl4-induced liver fibrosis in rats .
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Chemical structures of natural products with anti-inflammation activity,including genistein,salvianic acid A,botulin,and betulinic acid.
Salvianic acid A (Figure ),one of the most widely used natural products in China,is the main active component of Salvia miltiorrhiza (Danshen). In one study,treatment with salvianic acid A inhibited proliferation of HSCs and thus reduced the expression of TGF-β1 and collagen I/III. Decreased TGF-β1 levels led to inhibition of plasminogen activator,upregulation of the urokinase-type plasminogen activator,and dephosphorylation of Akt and ERK1/2 .
Betulin and its oxidized form betulinic acid (Figure ),a type of triterpene derived from the bark of Betula platyphylla var. japonica,can reverse alcohol-induced cytotoxicity in HepG2 cells . Treatment with betulin and betulinic acid inhibited expression of TNF-α,TGF-β1,tissue inhibitor of metalloproteinase (TIMP)-1,TIMP-2,and activated matrix metalloproteinase (MMP)-2 in alcohol-induced liver fibrosis in vivo .
The Chinese herbal formula,Gexia Zhuyu decoction (Gexia Zhuyu Tang; GZT),can attenuate fibrosis and reduce inflammation in the late stage of liver fibrosis . Treatment with GZT improved degeneration and inflammatory necrosis in liver cells,and reduced CCl4-induced collagen deposition in vivo .","department":"