新人999伤疤如何治疗配图，仅供参考
InjectablesIntralesional injections of anti-inflammatory and antimitotic agents
have been widely employed to treat and prevent the formation of hypertrophic
scarring. Intralesional corticosteroids,most commonly triamcinolone,are a
prominent therapy for hypertrophic scars and have been effective in improving
pigmentation and texture of formed scars . Treatment regimens,including dose,frequency,and duration of triamcinolone injections are variable and range from
10 to 40mg/ml every two to four weeks for a series of treatments until clinical
improvement of the scar is observed. As a stand-alone treatment triamcinolone
injection has demonstrated a response rate in 50–100% of
patients,however initial success is tempered by high rates of recurrence and
side-effects including hypo-pigmentation (more common in Fitzpatrick 3 and
higher),ulceration,and itching at the site of administration . As such,intralesional
corticosteroid injections are often used in conjunction with other treatment
modalities including surgery,and laser treatment to synergistically improve
outcomes. Additionally,the surgeon must not inject too much corticosteroid at a
single treatment (especially in children) to avoid adrenal insufficiency. Other
injectable modalities include,anti-neoplastic agents such as 5- fluorouracil
(5-FU) and Bleomycin,as well as antibiotics such as Mitomycin C and have been
employed to similar effect . Similar to triamcinolone,these anti-mitotic agents have
been demonstrated to reduce angiogenesis and diminish the proliferation of
fibroblasts in the wound bed. 5-FU is a pyrimidine analogue anti-metabolite,and
was initially shown to reduce the proliferation of fibroblasts in culture
. Clinically,the
drug has been used most often in combination with corticosteroids and other
treatment modalities including pulsed-dye-laser therapy. Combination therapy
demonstrates significant resolution of hypertrophic scarring,and furthermore,treatment with 5-FU mitigates the adverse effects induced by steroid injection
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